目的:通过计算机模拟及体外椎体标本实验，研究负压引导下骨水泥在骨质疏松椎体中的分布规律。方法:以椎体CT平扫为基础建立椎体模型，模拟骨水泥注入模型的过程及分布情况。选择老年女性的尸骨共20个椎体标本，形态结构相似的相邻节段椎体分别分入实验组(负压引导下经皮椎体成形术，VPVP组)与对照组(经皮椎体成形术，PVP组)，均行双侧椎弓根穿刺，实验组一侧低压注入骨水泥3 ml，对侧负压引导，对照组无负压引导。以SPSS 13.0分析比较两种方法骨内压并阐述骨水泥分布的规律，组间数据采用配对样本的n t检验。n 结果:模拟结果发现穿刺椎体中前二分之一，骨水泥团块在椎体内分布满意。吸引负压在40、60、100 kPa(1 kPa＝7.5 mmHg)时分布形态及相对填充度一致。体外实验中负压吸引组术中测得穿刺点骨内压为(42.52±5.09) kPa，显著低于对照组(n t＝-36.443，n P<0.05)，差异有统计学意义。负压吸引组相对分布体积[(47.91±8.70)%]大于对照组[(28.86±5.78)%，n t＝15.113，n P<0.05]，差异有统计学意义。n 结论:通过计算机模拟和体外实验结果证明，负压引导下椎体成形可以改善骨水泥在模型和尸体椎体标本内的空间分布并降低骨水泥注射时椎体内压力。“,”Objective:To study the distribution of bone-cement in osteoporotic vertebraes under vacuuming guidance by computer simulation and n in vitro experiment.n Methods:The vertebra computer model was established based on the vertebral computed tomography (CT)-scan data to simulate the process and distribution of bone cement. Totally 20 cadaveric vertebras were collected and adjacent vertebrae with similar morphology and structure were divided into the experimental group and the control group. Both groups were treated with bilateral pedicle puncture, and 3 ml bone cement was injected from one side, and the opposite side was guided by negative pressure in experiment group. Analysis of the intraosseous pressure along with the law of bone-cement distribution was done by statistical product and service solutions (SPSS) 13.0. Paired sample n t-test was used to analyze data between groups.n Results:The simulation results showed that the needle position should be located in the anterior half of the vertebral body, with the bone cement mass being well distributed in the vertebrae. When the vacuuming pressure was 40, 60, 100 kPa, the distribution patterns were similar and consistent. In the n in vitro experiment, the intraosseous pressure was significantly lower in experiment group than in control group (n t=-36.443, n P<0.05). The relative volume of bone cement in the experiment group [(47.91±8.70)%] was larger than that in the control group [(28.86±5.78)%,n t=15.113, n P<0.05]. The above experimental results were statistically significant.n Conclusion:The results of computer simulation and n in vitro experiments show that vacuuming percutaneous vertebroplasty can improve the spatial distribution of bone cement in both computer vertebrae model and cadaveric vertebral specimens with the intraosseous pressure being reduced.n