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目的评价胸腺扩大切除术术后重症肌无力(myasthenia gravis,MG)的远期疗效及预后的影响因素。方法回顾性分析2005年1月至2010年12月我院共施行胸腺扩大切除术治疗重症肌无力45例患者的临床资料,其中男11例、女34例,年龄32.6(16~50)岁。对所有患者进行随访,计算有效率,了解疗效随时间的变化,并对患者性别、年龄、Osserman分型、病理类型进行单因素分析。结果 45例完成随访,随访率100%,随访时间58.3(36~108)个月。有效率80.0%(36/45),随访时间越长有效率越高。影响重症肌无力疗效的单因素分析表明,性别(P=0.666)不是MG预后的影响因素,而年龄(P=0.019)、Osserman分型(P=0.024)和病理类型(P=0.043)是预后的影响因素。结论胸腺扩大切除术远期疗效满意,且随访时间越长预后更好。
Objective To evaluate the long-term efficacy and prognosis of myasthenia gravis (MG) after thymectomy. Methods The clinical data of 45 patients with myasthenia gravis treated with thymectomy in our hospital from January 2005 to December 2010 were retrospectively analyzed. There were 11 males and 34 females, aged 32.6 (16-50 years). Follow-up was performed on all patients, the effective rate was calculated, and the curative effect was observed over time. Univariate analysis was performed on patients’ gender, age, Osserman classification and pathological type. Results 45 cases were followed up, the follow-up rate was 100% and the follow-up time was 58.3 (36-108) months. The effective rate was 80.0% (36/45). The longer the follow-up period, the higher the efficiency. Univariate analysis showed that gender (P = 0.666) was not the prognostic factor for MG, but age (P = 0.019), Osserman classification (P = 0.024) and pathological type The impact of factors. Conclusions Long-term thymus enlargement resection is satisfactory, and the longer the follow-up period, the better prognosis.