为研究巨噬细胞功能在乙肝后肝纤维化免疫发病机制中的作用,我们采用ABC-ELISA及放射免疫测定法检测了33例急性乙肝炎,31例乙肝后肝硬化患者血中IFN-γ、PGE_2的水平.结果表明,急性乙肝患者与正常组比较,这两种因子的水平无明显变化;乙肝后肝硬化组显著异常.间接反映了分泌这两种细胞因子的巨噬细胞免疫功能紊乱,提示巨噬细胞的免疫功能在乙肝后肝纤维化发病机制中起着重要的免疫调控作用. To investigate the role of macrophage function in the pathogenesis of posthepatitis B-induced liver fibrosis, ABC-ELISA and radioimmunoassay were used to detect the levels of IFN-γ in 33 patients with acute hepatitis B and 31 patients with posthepatitic cirrhosis, PGE 2 levels.The results showed that acute hepatitis B patients compared with the normal group, the two factors had no significant changes in the level of hepatitis B cirrhosis was significantly abnormal, indirectly reflects the secretion of these two cytokines macrophage immune dysfunction, It is suggested that the immune function of macrophages plays an important immunoregulatory role in the pathogenesis of posthepatitic cirrhosis.