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Objective:To investigate the expressions of heat shock protein(hsp) 10,hsp27,hsp60,hsp70 and hsp90a in esophageal squamous cell carcinoma (ESCC) and normal lissues along the incisal margin (TIM),and discuss the clinico-pathologic features about their expressions.Methods:120 specimens from ESCC and 36 specimens from TIM were made into tissue chips.The presence and the levels of expression of hsp10,hsp27,hsp60,hsp70 and hsp90a were observed on tissue chips by immunohistochemistry EnVisionTM.Their correlations to clinicopatholoqic features were analyzed.Results:The positive staining rates of hsp10,hsp27,hsp60,hsp70 and hsp90a in ESCC and TIM were 53.8%and 37.5%,62.O%and 42.1%,92.7%and 63.2%.57.9%and 22.2%,33.7%and 18.5%respectively.There were no statistical significances between the difierential expressions of hsp10,hsp27 and hsp90a in ESCC and TIM(P＞0.05),bul there were great statistical significances about hsp60 and hsp70(P＜0.01).The level of hsp27 declined with the lower grade of differentiation of ESCC(P＜0.05).Except for hsp27.the positive expressions of the other four HSPs had no correlation to the clinicopathologic features of ESCC.Conclusion:The expressions of hsp10.hsp27.hsp60.hsp70 and hsp90a in ESCC and TIM were a common event.The levels of hsp60 and hsp70 in ESCC were higher than those in TIM.The level of hsp27 declined with the lower grade of differentiation of ESCC showed that it may be play a role in the differentiation of ESCC.