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为探讨甲醛、乙醛和丙烯醛对ＤＮＡ损伤机制，应用紫外光谱对甲醛、乙醛、丙烯醛三种醛类化合物引起的ＤＮＡ的加合反应，及与四种单核苷酸作用情况进行了研究。结果表明：甲醛、乙醛均引起小牛胸腺ＤＮＡ的第二个最大吸收峰（２５７ｎｍ）长波方向位移；同时也初步确定了甲醛、乙醛和四种单核苷酸结合的优势反应核苷酸。由于丙烯醛的紫外吸收谱图掩盖了ＤＮＡ的两个最大吸收峰（２１３ｎｍ，２５７ｎｍ），因此不能确切得出丙烯醛与小牛胸腺ＤＮＡ的加合反应情况。
In order to explore the mechanism of DNA damage to formaldehyde, acetaldehyde and acrolein, the adduct of DNA induced by three aldehydes such as formaldehyde, acetaldehyde and acrolein and the interaction with four kinds of mononucleotides the study. The results showed that formaldehyde and acetaldehyde all induced the long wave shift of the second maximum absorption peak (257nm) of calf thymus DNA. At the same time, the dominant reactive nucleotides of formaldehyde, acetaldehyde and four kinds of mononucleotides . As the acrolein UV absorption spectra mask the two maximum absorption peaks of DNA (213 nm, 257 nm), the exact reaction of acrolein with calf thymus DNA can not be obtained.