2000年11月6日美国食品与药品管理局发布了停用含有苯丙醇胺(PPA)成分的药物的通知。这是因为由耶鲁大学的一项调查研究的结果而引起的,认为服含有PPA成分的制剂会产生对于药物的过敏甚至引发心脏病以及脑中风的情况。美国食品与药品管理局这一决定引起了广泛的影响,迅速的波及到世界的各个国家。也就是此次事件使得人们重新对于药物安全性问题进行了重视,尤其对于上市后的药品在评价的问题。要想解决这些不良反应 November 6, 2000 The U.S. Food and Drug Administration released a notice to discontinue the use of PPA-containing drugs. This is due to the results of a survey conducted by Yale University that believed that preparations containing PPA ingredients can cause allergies to drugs and even lead to heart disease and stroke. The decision by the U.S. Food and Drug Administration has had a wide-ranging impact and quickly spread to all countries in the world. That is to say, this incident made people pay more attention to the problem of drug safety, especially for the listed drugs after evaluation. To solve these adverse reactions