复发性流产的病因及预防方法仍是需解决的重要问题,母胎免疫失调是当前的研究热点之一。调节性T细胞(Tregs)是一类控制体内自身免疫反应的T细胞亚群。研究认为,Tregs可能参与了母体接受同种异源体(胚胎)这一复杂的免疫调节过程,并能协助胎儿躲避母体免疫系统的攻击。因此,Tregs功能失调可能引起母体对胎儿的免疫排斥,最终导致复发性流产的发生。 The etiology and prevention of recurrent spontaneous abortion is still an important issue to be solved. Maternal-fetal immune disorder is one of the current research hotspots. Regulatory T cells (Tregs) are a subset of T-cells that control the autoimmune response in vivo. Studies suggest that Tregs may be involved in the complex immunomodulatory process in which the mother receives allogeneic embryos and help the fetus to evade maternal immune system attacks. Therefore, Tregs dysfunction may cause maternal immune rejection of the fetus, eventually leading to recurrent spontaneous abortion.