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目的:探讨腹腔镜和开腹子宫全切术对患者机体免疫功能的影响。方法:90例良性子宫疾病需行子宫全切除患者被随机分为开腹组和腹腔镜组,记录两组患者术中、术后情况,同时测定和比较两组患者手术前后T淋巴细胞亚群的变化情况。结果:①手术前后腹腔镜组患者外周血T淋巴细胞亚群CD3+、CD4+及CD4+/CD8+均无明显变化(P>0.05);而与术前比较,开腹组患者术后24h和72h外周血T淋巴细胞亚群CD3+、CD4+及CD4+/CD8+均有所下降(P<0.05)。②腹腔镜组患者术中出血量、排气时间、住院时间及术后并发症发生率均低于开腹组(P<0.05)。结论:腹腔镜全子宫切除术具有术中出血少、术后恢复快、并发症少的优点,且对机体免疫功能影响较开腹手术更小。
Objective: To investigate the effect of laparoscopic and open hysterectomy on the immune function of patients. Methods: Totally 90 patients with benign uterine diseases undergoing hysterectomy were randomly divided into laparotomy group and laparoscopic group. The intraoperative and postoperative conditions of both groups were recorded. T lymphocyte subsets of both groups were measured and compared before and after operation Changes in the situation. Results: ①There was no significant change of T lymphocyte subsets CD3 +, CD4 + and CD4 + / CD8 + in the peripheral blood of patients before and after laparoscopic surgery (P> 0.05) T lymphocyte subsets CD3 +, CD4 + and CD4 + / CD8 + decreased (P <0.05). ② The intraoperative laparoscopic group bleeding, exhaust time, hospital stay and postoperative complications were lower than the open group (P <0.05). Conclusions: Laparoscopic hysterectomy has the advantages of less intraoperative bleeding, faster recovery and fewer complications, and has less impact on the immune function than laparotomy.