为了进一步了解热中子致死作用的机理,作者研究了热中子和几种化学因子对DNA作用的协同效应,这些因子主要是争光霉素和放线菌素D。发现争光霉素即使在很低浓度中亦有显著的致敏感作用,而对放线菌素D来说,在很低浓度时只有轻微的或者不呈现致敏感作用,虽然在其高浓度时有明显的致敏感效应(在100微克/毫升时)。在照射前给药的致敏感效应要比照射后给药强的多。而且在 In order to further understand the mechanism of thermal neutron lethality, the authors studied the synergistic effect of thermal neutrons and several chemical factors on DNA action. These factors are mainly bleomycin and actinomycin D. It was found that bleomycin has significant sensitization even at very low concentrations, whereas for actinomycin D there is only slight or no sensitization at very low concentrations, although at high concentrations there are Obvious sensitization effect (at 100 μg/ml). The sensitisation effect of administration before irradiation is much stronger than that after irradiation. And in