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1996年6月,在日本发明协会公布的22项全国发明奖获奖中,有3项医药发明,现简介如下。 1.可口服的PGI_2衍生物Beraprost sodium 1976年发现的生物体内物质PGI_2是一种具有强血管扩张和抑制血小板凝结作用的物质,因此认为极有可能成为治疗心肌梗塞、脑血管梗塞的药物。但是,由于PGI_2非常不稳定,作为药物使用必须改善其化学稳定性,同时保证它在生物体内代谢时的稳定性,消除副作用。
In June 1996, among the 22 national invention awards announced by the Japan Invention Association, there were 3 medical inventions, which are summarized below. 1. Orally available PGI 2 derivatives Beraprost sodium PGI 2 was found in 1976 to be a substance with strong vasodilation and inhibition of platelet aggregation. Therefore, it is considered to be a drug that can treat myocardial infarction and cerebrovascular infarction. However, since PGI 2 is very unstable, it is necessary to improve its chemical stability as a drug, and at the same time to ensure its stability during metabolism in the living body and eliminate side effects.