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对２３例经病理学证实的中晚期肺癌患者之手术标本，进行了肺癌组织细胞中ＤＮＡ含量、线粒体和细胞浆中谷胱甘肽（ＧＳＨ）含量、谷胱甘肽硫转移酶（ＣＳＴ）及肌酸磷酸激酶（ＣＫ）的亚细胞分布研究，旨在协助临床寻找肺癌诊断的特异标志．结果表明：（１）２３例患者ＤＮＡ指数（ＤＩ）分级均为Ⅲ级，ＤＮＡ定量测定均为异倍体或多倍体，与正常上皮细胞的ＤＩ相比，其升高的程度有非常显著意义（Ｐ＜０．０ｌ）；（２）癌组织（鳞癌和腺癌）胞浆中ＣＳＨ含量较正常组织明显增加，其差异均有显著意义（Ｐ＜０．０１）．线粒体中ＧＳＨ含量只有鳞癌组织增加的有显著意义（Ｐ＜０．０１）：（３）鳞癌组织（胞浆和线粒体）和腺癌组织的胞浆中ＧＳＴ活性较相应的正常组织均明显升高，其差异均有显著意义．结果提示：ＧＳＨ含量和ＧＳＴ活性水平的检测对于肺癌的诊断可能是一个有用的指标。
The surgical specimens of 23 patients with advanced lung cancer confirmed by pathology were examined for DNA content, glutathione (GSH) content in mitochondria and cytoplasm, glutathione-S-transferase (CST), and muscle in lung cancer tissue cells. The subcellular distribution of acid phosphokinase (CK) is designed to assist clinical search for specific markers of lung cancer diagnosis. The results showed that: (1) All 23 patients had grade III DNA index (DI) and all DNA was quantitatively aneuploid or polyploid. Compared with DI of normal epithelial cells, the degree of increase was very significant. Significance (P<0.0l); (2) The CSH content in the cytoplasm of cancer tissue (squamous cell carcinoma and adenocarcinoma) was significantly increased compared with normal tissue, and the difference was significant (P<0.01). The mitochondrial GSH content was only significantly increased in squamous cell carcinoma tissues (P<0.01). (3) The GST activity in the cytoplasm of squamous cell carcinoma tissues (cytoplasm and mitochondria) and adenocarcinoma tissues was significantly higher than that in normal tissues. Increased, the differences are significant. The results suggest that the detection of GSH content and GST activity may be a useful indicator for the diagnosis of lung cancer.