由福马林灭活的全菌体人用鼠疫疫苗因具有严重缺陷而限制了它的应用 ,间接证据表明这种疫苗对预防肺鼠疫无效 ,而且能引起局部和全身副反应。含鼠疫杆菌 F1抗原和 V抗原的无细胞亚单位疫苗的应用则可避免发生副反应 ,而且还能抵抗气溶胶攻击。作者应用 4种 H- 2单元型小鼠对亚 Whole-cell human plague vaccine inactivated by fmalin limits its utility due to its serious defects. Indirect evidence suggests that the vaccine is ineffective in preventing pneumonic plague and can cause both local and systemic side effects. The use of cell-free subunit vaccines containing the Yersinia pestis F1 antigen and the V antigen prevents side effects and also resists aerosol attacks. The authors applied four H-2 haplotype mouse pairs to Asia