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目的:建立顶空气相色谱法测定灯盏花滴丸中的有机溶剂乙醇、正丁醇残留量的方法。方法:采用DB-624毛细管柱(30 m×0.32 mm,1.8μm),载气为氮气,柱温为100℃,进样口温度为200℃,FID检测器温度为250℃,顶空平衡温度85℃,顶空平衡时间为45 min。结果:乙醇、正丁醇在0.02～1.00 mg.ml-1(r=0.999 7)的浓度范围内呈良好的线性关系;平均回收率分别为乙醇101.1%(RSD为3.3%),正丁醇105.0%(RSD为2.6%)。结论:该方法快速、灵敏、准确,可用于灯盏花滴丸中有机溶剂残留量的测定。
Objective: To establish a method for the determination of organic solvent ethanol and n-butanol in Erigeron Breviscapus drops by headspace gas chromatography. Methods: The DB-624 capillary column (30 m × 0.32 mm, 1.8 μm) was used. The carrier gas was nitrogen and the column temperature was 100 ℃. The inlet temperature was 200 ℃, the FID detector temperature was 250 ℃, 85 ℃, headspace balance time is 45 min. Results: The ethanol and n-butanol showed good linearity in the range of 0.02-1.00 mg.ml-1 (r = 0.999 7). The average recoveries were 101.1% ethanol (RSD 3.3%), n-butanol 105.0% (RSD 2.6%). Conclusion: The method is rapid, sensitive and accurate and can be used for the determination of organic solvent residues in Dengzhanhua drop pills.