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目的:运用Meta分析方法研究硫普罗宁对于抗结核药所致肝损伤治疗效果,评价其临床应用。方法:检索有关用硫普罗宁或其商品名(凯西莱)对抗结核药所致肝损伤治疗的临床随机对照文献,运用RevMan软件分析对照试验治疗后丙氨酸转氨酶(ALT)、天门冬氨酸转氨酶(AST)、总胆红素(TB)综合定量结果。根据资料的异质性检验,均采用随机效应模型,计算合并加权均数差(WMD)及其95%可信区间(CI)。结果:(1)资料的异质性检验:肝功能测量指标ALT、AST、BT的异质性检验I2≥50%,具有异质性。(2)Meta分析结果:ALT、AST、BT的WND均不包括0,结果均有统计学意义,分别是-20.08(95%CI为-22.23～-17.941),-14.49(95%CI为-17.02～-11.96),-4.09(95%CI为-5.04～-3.14)。结论:硫普罗宁对于抗结核药所致肝损伤有较好的治疗效果。
OBJECTIVE: To study the clinical effect of tiopronin in the treatment of hepatic injury induced by anti-TB drugs by Meta-analysis. METHODS: A randomized controlled clinical trial was conducted to investigate randomized controlled trials on the treatment of liver damage caused by antithrombotic agents with tiopronin or its trade name (Ketaisel). The effects of atrial natriuretic peptide (ALT), aspartate Acid aminotransferase (AST), total bilirubin (TB) comprehensive quantitative results. According to the data heterogeneity test, the random effects model was used to calculate the WMD and 95% Confidence Interval (CI). Results: (1) Heterogeneity test of data: heterogeneity test of ALT, AST, BT in liver function measurement I2≥50%, with heterogeneity. (2) Results of Meta-analysis: WND of ALT, AST and BT did not include 0, the results were statistically significant, which were -20.08 (95% CI -22.23 ~ -17.941), -14.49 (95% 17.02 ~ -11.96), -4.09 (95% CI -5.04 ~ -3.14). Conclusion: Tiopronin has good therapeutic effect on liver injury caused by anti-TB drugs.