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目的探讨卵巢上皮性肿瘤中PIEN和Survivin的表达及意义。方法采用免疫组织化学法检测PTEN和survivin在52例卵巢上皮性癌、20例卵巢良性上皮性肿瘤和18例正常卵巢组织标本中的表达。结果正常卵巢组织中无Survivin蛋白表达,良性上皮性卵巢肿瘤和卵巢上皮性癌中Survivin蛋白表达率分别为26.32%(5/19)、66.67%(30/45),卵巢上皮性癌中Survivin蛋白阳性表达率明显高于正常卵巢及良性上皮性卵巢肿瘤组,差异有显著性(P<0.05);PTEN蛋白在正常卵巢组织、卵巢良性上皮性肿瘤和卵巢上皮性癌中的表达率分别为100.0%(18/18)、95.0%(20/19)、38.5%(20/52)。PTEN蛋白在正常卵巢组织及卵巢良性上皮性肿的表达率均高于卵巢上皮性癌(均P<0.01)。结论 PTEN的表达下降和Survivin的表达上升与卵巢上皮性癌的发生相关,检测卵巢癌患者癌组织中PIEN和SUrvivin的表达水平对于评价卵巢癌的恶性程度、和估计预后具有重要临床价值。
Objective To investigate the expression and significance of PIEN and Survivin in epithelial ovarian tumors. Methods The expressions of PTEN and survivin in 52 cases of epithelial ovarian cancer, 20 cases of benign epithelial ovarian tumor and 18 cases of normal ovarian tissue were detected by immunohistochemistry. Results There was no Survivin protein expression in normal ovarian tissue. The positive rates of Survivin protein in benign epithelial ovarian tumor and epithelial ovarian cancer were 26.32% (5/19) and 66.67% (30/45), respectively. Survivin protein in ovarian epithelial carcinoma The positive expression rate of PTEN protein in normal ovarian tissues, benign epithelial ovarian tumor and epithelial ovarian cancer was significantly higher than that in normal ovarian and benign epithelial ovarian tumors (P <0.05) % (18/18), 95.0% (20/19), 38.5% (20/52). The positive rates of PTEN protein in normal ovarian tissues and benign ovarian epithelial tumors were significantly higher than those in epithelial ovarian cancer (all P <0.01). Conclusions The decrease of PTEN expression and the increase of Survivin expression are correlated with the occurrence of epithelial ovarian cancer. Detecting the expression of PIEN and SUrvivin in ovarian cancer tissue has important clinical value in evaluating the malignancy of ovarian cancer and prognosis.