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目的探讨血液灌流(hemoperfusion,HP)对治疗急性有机磷中毒(acute organophosphorus poisoning,AOPP)的疗效。方法统计2010年1月-2012年1月行HP治疗的19例AOPP患者与未行HP治疗的23例患者的临床资料,比较乙酰胆碱酯酶(serum cholinesterase,ChE)恢复到正常值的70%时间及治疗后1,3,5天ChE值,ChE复活剂总用量,总疗程阿托品用量,入院时患者达到阿托品化用量及1,3,5天患者阿托品用量,临床症状缓解时间,住院时间,中间综合征发生率,病死率等指标。结果 ChE恢复至正常值的70%时间及3,5天ChE值,ChE复活剂总用量,总疗程阿托品用量,入院后3,5天患者阿托品用量,中间综合征发生率、病死率等指标两组间差异均有统计学意义(P<0.05)。结论 HP治疗有机磷中毒效果明显。
Objective To investigate the therapeutic effect of hemoperfusion (HP) on acute organophosphorus poisoning (AOPP). Methods The clinical data of 19 patients with AOPP who underwent HP treatment from January 2010 to January 2012 were compared with 23 patients who did not receive HP therapy. The serum cholinesterase (ChE) was recovered to 70% of the normal value And 1, 3, 5 days after treatment, the ChE value, the total amount of ChE resuscitator, the total course of atropine dosage, the patients on the admission to achieve the amount of atropine and 1,3,5 days of patients with atropine dosage, clinical symptom relief time, hospital stay, Syndrome incidence, mortality and other indicators. Results ChE returned to normal value of 70% of the time and 3,5 days ChE value, the total amount of ChE resuscitation dose, the total course of treatment of atropine, 3,5 days after admission in patients with atropine dosage, intermediate syndrome incidence, mortality and other indicators of two Differences between groups were statistically significant (P <0.05). Conclusion HP treatment of organophosphate poisoning effect is obvious.