论文部分内容阅读
目的探讨显微外科手术联合术后放疗治疗脊髓髓内胶质瘤的临床疗效。方法回顾性分析2010年2月至2014年4月在手术治疗的53例脊髓髓内胶质瘤患者的临床资料,分析其疗效。结果 23例室管膜瘤患者中,13例患者行次全切除术,10例患者行全切除术,其中2例患者术后进行放疗治疗。30例星形细胞瘤患者中,12例患者行大部分切除术,18例患者全切除术,30例术后均接受放化疗治疗。53例患者Mccormck分级Ⅰ级10例、Ⅱ级19例、Ⅲ级3例和Ⅳ级3例。改善40例(79.2%),无变化10例(18.9%),加重3例(5.7%)。术后随访6个月至2年,其中1例星形细胞瘤大部分切除患者1年后临床表现症状加重,行磁共振成像检查显示无复发。结论脊髓髓内胶质瘤患者采取显微外科手术联合术后放疗,不仅可以切除肿瘤,还可保证患者的神经功能,提高患者的生活质量,值得临床推广。
Objective To investigate the clinical effects of microsurgery combined with postoperative radiotherapy for spinal intramedullary glioma. Methods The clinical data of 53 patients with spinal intramedullary glioma who underwent surgical treatment from February 2010 to April 2014 were analyzed retrospectively. The curative effect was analyzed. Results Of the 23 patients with ependymoma, 13 patients underwent subtotal resection and 10 patients underwent total resection. Two patients underwent radiotherapy after operation. Among 30 patients with astrocytoma, 12 patients underwent most resections, 18 patients underwent total resection and 30 patients received radiotherapy and chemotherapy after operation. Fifty-three patients had Mccormck grade Ⅰ in 10 cases, Ⅱ grade in 19 cases, Ⅲ grade in 3 cases and Ⅳ grade in 3 cases. 40 cases (79.2%) were improved, 10 cases (18.9%) were unchanged, and 3 cases (5.7%) were aggravated. The patients were followed up for 6 months to 2 years. Most of the patients with astrocytomas underwent resection of their clinical manifestations after 1 year, and their MRI findings showed no relapse. Conclusion Spinal intramedullary glioma patients with microsurgery combined with postoperative radiotherapy, not only can remove the tumor, but also to ensure the neurological function of patients and improve the quality of life of patients, it is worth clinical promotion.