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目的:观察人血白蛋白辅助治疗小儿难治性腹泻临床疗效。方法:60例符合小儿难治性腹泻诊断标准的患儿随机分为治疗组(32例)和对照组(28例),在积极常规治疗小儿难治腹泻的基础上,治疗组施用人血白蛋白0.5~1.0 g.kg-1.d-1静脉滴注,连用2~3天。结果:治疗组总有效率90.6%,对照组总有效率75.0%,两组比较差异无统计学意义(P>0.05)。治疗组平均治疗时间(5.9±2.7)天,对照组平均治疗时间(9.6±3.1)天,两组比较差异有统计学意义(P<0.01)。治疗组低蛋白血症纠正率100.0%,对照组纠正率53.3%,两组比较差异有统计学意义。结论:小儿难治性腹泻病在常规治疗的基础上施用人血白蛋白为机体提供营养,可缩短治疗时间,加快病情康复。
Objective: To observe the clinical efficacy of human albumin in the treatment of refractory diarrhea in children. Methods: Sixty children with refractory diarrhea were randomly divided into treatment group (n = 32) and control group (n = 28). On the basis of active routine treatment of refractory diarrhea in children, Protein 0.5 ~ 1.0 g.kg-1.d-1 intravenous infusion, once every 2 to 3 days. Results: The total effective rate was 90.6% in the treatment group and 75.0% in the control group. There was no significant difference between the two groups (P> 0.05). The mean treatment time was 5.9 ± 2.7 days in the treatment group and 9.6 ± 3.1 days in the control group. The difference between the two groups was statistically significant (P <0.01). In the treatment group, the rate of hypoproteinemia was 100.0% and that of the control group was 53.3%. There was significant difference between the two groups. Conclusion: The treatment of infantile intractable diarrhea on the basis of routine treatment of human serum albumin to provide nutrition for the body, can shorten the treatment time and speed up the rehabilitation of the disease.