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目的:探讨以顽固性呃逆、恶心(intractable hiccup and nausea,IHN)起病的视神经脊髓炎谱系疾病(neuromyelitis optica spectrum disorders,NMOSD)临床特点。方法:分析总结2例以IHN起病的NMOSD患者的临床资料,并复习相关文献。结果:2例NMOSD患者首次发病均表现为IHN,随后在短时间内出现临床复发。其中病例1患者在2周后出现脑干症状、脊髓炎,并在半年后出现视神经炎;病例2患者在2个月后出现长节段横贯性脊髓炎(longitudinally extensive transverse myelitis,LETM)。2例患者血清水通道蛋白-4(aquaporin-4,AQP-4)抗体阳性,支持NMOSD诊断。结论:临床上以IHN起病的NMOSD诊断易被延误。
Objective: To investigate the clinical features of neuromyelitis optica spectrum disorders (NMOSD) with onset of intractable hiccup and nausea (IHN). Methods: The clinical data of 2 patients with NMOSD who had IHN onset were reviewed and reviewed. Results: The first onset of 2 patients with NMOSD showed IHN, followed by clinical relapse in a short period of time. Among them, patient 1 had brainstem symptoms and myelitis after 2 weeks and optic neuritis after 6 months; patient 2 had longinterior transverse myelitis (LETM) after 2 months. Two cases of patients with positive serum aquaporin-4 (AQP-4) antibodies, support the diagnosis of NMOSD. Conclusion: The clinical diagnosis of Iodosis with IHN is easily delayed.