目的 :观察溶栓合剂对深静脉血栓形成纤溶功能的影响。方法 :制作家兔颈外静脉血栓形成模型。观测溶栓合剂对组织型纤溶酶原激活剂 (t-pA)活性 ,纤溶酶原激活抑制剂 (PAI)活性 ,及体内血栓干重的影响。结果 :溶栓合剂治疗组t- pA活性明显提高 ,PAI活性 ,体内血栓干重明显降低 ,与造模组比较 ,差异显著 (P <0 .0 5 )。结论 :溶栓合剂有明显促进纤溶系统活性及抗血栓形成的作用 Objective : To observe the effect of thrombolytic agent on fibrinolytic function of deep vein thrombosis. Methods: A rabbit model of external jugular vein thrombosis was established. Observed the effect of thrombolytic agent on tissue plasminogen activator (t-pA) activity, plasminogen activator inhibitor (PAI) activity, and dry weight of thrombus in vivo. Results: The activity of t-pA was significantly increased in the thrombolytic mixture group. The activity of PAI and the dry weight of thrombus in vivo were significantly decreased. There was a significant difference compared with the model group (P < 0.05). Conclusion : The thrombolytic mixture can significantly promote the activity of fibrinolytic system and its antithrombotic effect