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利用血卟啉衍生物中的某些成份在肿瘤组织中选择性聚积的生化特性及其光敏的自然特性,能进行肿瘤的光动力学定位和光动力学治疗。但血卟啉衍生物的成份及其体内代谢具有一定复杂性。确定、纯化、合成高肿瘤亲和力高光敏活性的血卟啉衍生物成份,明确其体内代谢尤其是肿瘤中的代谢规律,能提高、血卟啉衍生物的肿瘤特异的光动力学效应,进而提高其在肿瘤学中的应用价值。本文还讨论了血卟啉衍生物在肿瘤的定位、定性诊断中的应用及其前景。
The photodynamic localization and photodynamic therapy of tumors can be performed by utilizing the biochemical characteristics of selective accumulation of certain components of hematoporphyrin derivatives in tumor tissues and their natural photosensitivity. However, the components of hematoporphyrin derivatives and their metabolism in vivo have certain complexity. Determine, purify, and synthesize high-sensitivity photosensitivity hematoporphyrin derivatives with high tumor acuity, define their metabolism in vivo, especially in tumors, and improve the tumor-specific photodynamic effects of hematoporphyrin derivatives, thereby increasing Its application value in oncology. This article also discusses the application and prospects of hematoporphyrin derivatives in the localization and qualitative diagnosis of tumors.