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目的:观察自体富血小板纤维蛋白(Platelet-rich fibrin,PRF)膜片修补口腔上颌窦瘘的临床疗效。方法:选取解放军第425医院疗养区眼耳鼻喉科2010年4月到2013年4月间24例上颌窦瘘患者,采用随机分组,其中A组12例患者各采静脉血20 mL制备PRF膜片修补上颌窦瘘,另外B组12例患者采用组织瓣法修补上颌窦瘘,比较两组患者的伤口一期愈合成功率以及6-12月后随访预后并进行统计学分析。结果:PRF膜片修补组手术均获得成功,而组织瓣修补组中采用带蒂颚粘膜瓣有1例失败,两组间一期愈合成功率无显著差异(P=0.755),随访发现颊侧黏骨膜瓣修补的患者术后口腔前庭沟均有不同程度变浅,而其它修补方法术后前庭沟无明显异常。结论:自体PRF膜片制备简单,用其修补上颌窦瘘效果确切,手术简单,并发症少,可应用于临床实践。
Objective: To observe the clinical effect of repairing oral maxillary sinus fistula with platelet-rich fibrin (PRF) patch. METHODS: Twenty-four cases of maxillary sinus fistula from April 2010 to April 2013 in the Department of Otolaryngology and Otolaryngology, People’s Liberation Army 425th Hospital, were randomly divided into groups, of which 12 patients in group A received 20 mL venous blood to prepare PRF membrane Repair of maxillary sinus fistula, the other group B group of 12 patients with flap repair of maxillary sinus fistula, the two groups of patients compared the success rate of wound healing and follow-up after 6-12 months of follow-up and statistical analysis. Results: The operation of PRF patch repair group was successful. One case failed with pedicled palatal mucosa flap in the flap repair group. There was no significant difference in the success rate of primary healing between two groups (P = 0.755). The buccal Mucoperiosteal flap repair in patients with oral vestibular groove have varying degrees of shallow, and other repair method of the posterior chamber ditch without obvious abnormalities. CONCLUSION: The preparation of autologous PRF membrane is simple, its effect of repairing maxillary sinus fistula is exact, the operation is simple, the complication is less and it can be used in clinical practice.