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目的:研究白介素-2在经完全福氏佐剂处理的、对吗啡镇痛作用不敏感大鼠上的镇痛作用.方法:以由伤害性热刺激所引起的抬腿潜伏期作为大鼠痛阈来研究药物的镇痛作用.结果:在正常大鼠足底局部注射人重组白介素-2(1.5×10~4 U)能够显著提高痛阈,此镇痛作用被μ-阿片肽受体的拮抗剂纳络酮(1 mg/kg,ip)部分翻转.在对吗啡不敏感的经福氏佐剂处理的动物上,白介素-2仍具有显著的镇痛作用,但较之于在正常动物上的则明显降低.在经完全福氏佐剂处理的动物上,纳络酮不对白介素-2的镇痛作用产生影响.结论:μ-阿片肽受体部分介导了白介素-2的镇痛作用;白介素-2具有潜在的临床应用价值以治疗对吗啡不敏感的疼痛.
OBJECTIVE: To study the analgesic effect of interleukin-2 (IL-2) in rats which are not sensitive to the analgesic effect of morphine after complete Freund’s adjuvant treatment.Methods: The latency of leg raising caused by noxious heat stimulation To study the analgesic effect of drugs.Results: Local injection of human recombinant interleukin-2 (1.5 × 10 ~ 4 U) in the soles of rats could significantly increase the pain threshold, and the analgesic effect was antagonized by μ-opioid receptor Part naloxone (1 mg / kg, ip) was partially overturned.It was found that interleukin-2 still had a significant analgesic effect on morphine-insensitive animals treated with Freund’s adjuvant, Was significantly reduced on nauplii, whereas naloxone did not affect the analgesic effect of interleukin-2 on animals treated with complete Freund’s adjuvant.Conclusion: μ-opioid receptor partially mediated interleukin-2 Pain; Interleukin-2 has potential clinical value to treat pain that is not sensitive to morphine.