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目的探讨血清25-羟基维生素D水平[25(OH)D]与育龄妇女营养状况的相关性。方法选取2016年1-12月在湖南省妇幼保健院健康体检的育龄妇女214例,检测25(OH)D、甲状旁腺(PTH)、空腹血糖、血清钙、磷等指标,以及胰岛素抵抗指数(HOMA-IR)。结果根据维生素D水平分组,维生素D缺乏组[25(OH)D]≤25nmol/L妇女106例,不足组[25nmol/L<25(OH)D]≤50 nmol/L 91例,适宜组[50<25(OH)D]≤75 nmol/L 17例;各组血清PTH、血钙、血磷、甘油三酯、空腹血糖、总胆固醇和糖化血红蛋白比较差异无统计学意义(P>0.05);维生素D适宜组HOMA-IR为(2.30±0.77),明显低于维生素D缺乏组和不足组(P<0.05);维生素D不足组HOMA-IR为(2.43±0.83),明显低于维生素D缺乏组(P<0.05);胰岛素抵抗妇女血清25(OH)D水平为(24.11±4.03)nmol/L,明显低于无胰岛素抵抗妇女(P<0.05);血清25(OH)D与HOMA-IR呈负相关(r=-0.277,P<0.05)。结论 25-羟基维生素D水平与育龄妇女胰岛素抵抗增加有关,与血清钙、磷、PTH等生化指标无明显关系。
Objective To investigate the correlation between serum 25-hydroxyvitamin D level [25 (OH) D] and nutritional status of women of childbearing age. Methods Two hundred and seventy women of childbearing age in healthy maternal and child health centers in Hunan Province from January to December in 2016 were enrolled in this study. The indexes of 25 (OH) D, PTH, fasting blood glucose, serum calcium and phosphorus were detected and insulin resistance index (HOMA-IR). The results were grouped according to the level of vitamin D in 91 patients with vitamin D deficiency [25 (OH) D] ≤25nmol / L in women and in less than 25 patients (25nmol / L <25 (OH) The serum levels of PTH, serum calcium, phosphorus, triglyceride, fasting blood glucose, total cholesterol and glycosylated hemoglobin were not significantly different between the two groups (P> 0.05) ; HOMA-IR in vitamin D-appropriate group was (2.30 ± 0.77), which was significantly lower than that in vitamin D deficiency group and deficient group (P <0.05); HOMA-IR in vitamin D deficiency group was (2.43 ± 0.83) (24.11 ± 4.03) nmol / L, significantly lower than those without insulin resistance (P <0.05); serum 25 (OH) D and HOMA- IR was negatively correlated (r = -0.277, P <0.05). Conclusions 25-hydroxyvitamin D is associated with an increase in insulin resistance in women of childbearing age, but not with serum calcium, phosphorus, PTH and other biochemical markers.