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目的:对多发性肌炎/皮肌炎(PM/DM)的预后及死亡因素进行相关分析。方法:对64例PM/DM患者进行10年以上追踪随访,以观察其发病年龄、性别、病种(PM/DM)、实验室检查、伴发的系统损害以及是否伴有恶性肿瘤等因素对预后及死亡的影响。结果:随访期间共死亡20例,病死率31.25%。5年生存率为78.13%,10年生存率为68.75%。发病年龄、性别、病种、血沉(ESR)、肌酸激酶(CK)、联合运用免疫抑制剂治疗6个因素与预后及死亡无相关性(均P>0.05)。而恶性肿瘤、肺间质病变与预后及死亡有显著相关性(均P<0.01)。结论:PM和DM预后及影响预后的因素国内外文献报道不多且结论不一,本组死亡的主要原因为肺间质病变伴感染和恶性肿瘤。
Objective: To analyze the prognosis and mortality of polymyositis / dermatomyositis (PM / DM). Methods: Sixty-four patients with PM / DM were followed up for more than 10 years to observe the factors such as their age, gender, disease type (PM / DM), laboratory tests, associated systemic damage and malignancy Prognosis and the impact of death. Results: Twenty patients died during follow-up, with a mortality rate of 31.25%. The 5-year survival rate was 78.13% and the 10-year survival rate was 68.75%. Age, sex, disease type, ESR, CK, and combination of immunosuppressive agents in treatment of 6 factors had no correlation with prognosis and death (all P> 0.05). There was a significant correlation between malignant tumor, interstitial lung disease and prognosis and death (all P <0.01). Conclusions: The prognosis of PM and DM and the prognostic factors are not many reported in the literature and the conclusions are different, the main cause of death in this group of patients with interstitial lung disease associated with infection and malignant tumors.