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目的:探讨青海地区足月新生儿急性呼吸窘迫综合征发病的高危因素,为临床本病防治措施的制定提供参考。方法:回顾性分析青海省妇幼保健院自2011年1月~2013年12月期间收治的急性呼吸窘迫综合征足月新生儿(观察组)以及健康分娩新生儿(对照组)各124例的临床资料。对比两组新生儿的各项临床资料,并通过多因素Logistic回归分析探讨青海地区足月新生儿急性呼吸窘迫综合征发病的高危因素。结果:观察组新生儿的剖宫产率、社会因素剖宫产的比例、发生宫内窘迫的比例、发生新生儿窒息的比例、发生羊水吸入的比例均显著高于对照组(P<0.05);多因素Logistic回归分析显示,社会因素剖宫产、宫内窘迫、新生儿窒息、羊水吸入是足月新生儿急性呼吸窘迫综合征发病的高危因素(P<0.05)。结论:社会因素剖宫产、宫内窘迫、新生儿窒息和羊水吸入是青海地区足月新生儿急性呼吸窘迫综合征发病的高危因素,临床上应尽量降低社会因素剖宫产率,积极防治宫内窘迫、新生儿窒息、羊水吸入,以进一步降低本病的发病风险。
Objective: To investigate the risk factors of acute respiratory distress syndrome in full-term newborn infants in Qinghai and to provide reference for the establishment of clinical prevention and treatment measures. Methods: A retrospective analysis of 124 cases of acute respiratory distress syndrome full-term newborns (observation group) and 124 healthy newborn infants (control group) admitted to Qinghai MCH from January 2011 to December 2013 data. The clinical data of two groups were compared. Logistic regression analysis was used to explore the risk factors of acute respiratory distress syndrome in full-term newborns in Qinghai. Results: The rate of cesarean section, social factors of cesarean section, intrauterine distress rate, neonatal asphyxia and amniotic fluid inhalation in observation group were significantly higher than those in control group (P <0.05) Logistic regression analysis showed that social factors cesarean section, intrauterine distress, neonatal asphyxia and amniotic fluid inhalation were the risk factors of acute respiratory distress syndrome in full-term newborns (P <0.05). Conclusion: Social factors cesarean section, intrauterine distress, neonatal asphyxia and amniotic fluid inhalation are the risk factors of acute respiratory distress syndrome in full-term newborns in Qinghai. Clinically, we should try our best to reduce the incidence of cesarean section rate in social factors, Internal distress, neonatal asphyxia, amniotic fluid inhalation, to further reduce the risk of the disease.