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本文从乙醛的毒性作用、乙醇代谢酶多态性、氧化应急、NADH/NAD+、CYP2E1等方面对酒精性肝病(ALD)的发病机制作了简要阐述,ALD的发病原因主要是乙醇在肝细胞内产生的毒性代谢产物及其引起的代谢紊乱。ALD分为酒精性脂肪肝、酒精性肝炎和酒精性肝硬化。其致病因素单一,即长期大量的酒精摄入,但发病机制较为复杂,目前尚未完全清楚。因此,继续研究ALD的发病机制非常有意义。
In this paper, the pathogenesis of alcoholic liver disease (ALD) is briefly described from the toxic effects of acetaldehyde, polymorphisms of ethanol metabolism enzymes, oxidative stress, NADH / NAD + and CYP2E1. The pathogenesis of ALD is mainly that of ethanol in hepatocytes Toxic metabolites produced within and caused by metabolic disorders. ALD is divided into alcoholic fatty liver, alcoholic hepatitis and alcoholic cirrhosis. Its single disease risk factors, that is, a large number of long-term alcohol intake, but the pathogenesis is more complex, is not yet fully understood. Therefore, continuing to study the pathogenesis of ALD is very meaningful.