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作者研究了蓖麻毒素对BALB/c雄性小鼠的毒性及对昆明种雄性小鼠骨髓多染性红细胞微核的影响.结果表明,BALB/c小鼠腹腔注射8 d后,6.4μg/kg剂量组体重由20.79±0.98 g降为19.62±1.00g,体重增长受到明显抑制(P<0.01);0.4,1.6和6.4μg/kg剂量组白细胞数目依次为9.070±0.751,9.210±0.801和8.270±0.396×10~9/L,与对照组(11.430±1.042×10~9/L)相比显著降低(P<0.05,0.05和0.01);脾和胸腺的重量则没有明显变化.昆明种小鼠腹腔注射24 h后,1.6和6.4μg/kg剂量组骨髓多染性红细胞微核率为21.90±4.28‰和29.26±3.48‰,与对照组(4.94±1.03‰)相比明显增高(P<0.01),且呈现出剂量 效应关系.此结果提示蓖麻毒素对小鼠有剧毒,对遗传物质也有较大的影响.
The authors studied the toxicity of ricin on BALB/c male mice and the effect on the micronucleus of bone marrow polychromatic erythrocytes of Kunming male mice. The results showed that after 8 days of intraperitoneal injection of BALB/c mice, 6.4μg/kg The weight of the dose group decreased from 20.79±0.98 g to 19.62±1.00 g, and the weight gain was significantly inhibited (P<0.01). The number of white blood cells in the 0.4, 1.6, and 6.4 μg/kg dose groups was 9.070±0.751, 9.210±0.801, and 8.270±, respectively. 0.396×10~9/L, significantly lower than the control group (11.430±1.042×10~9/L) (P<0.05, 0.05, and 0.01); no significant changes in spleen and thymus weights. Kunming mice After intraperitoneal injection for 24 h, the micronucleus rate of bone marrow polychromatic erythrocytes at the doses of 1.6 and 6.4 μg/kg was 21.90±4.28 ‰ and 29.26±3.48 ‰, which was significantly higher than that of the control group (4.94±1.03 ‰) (P<0.01). ), and showed a dose-effect relationship. This result suggests that ricin is highly toxic to mice and has a greater impact on genetic material.