论文部分内容阅读
目的探讨新生儿分别接种10μg与5μg乙型肝炎(乙肝)疫苗免疫后不同时间免疫水平,为调整新生儿乙肝疫苗免疫程序提供科学依据。方法采用病例对照研究方法观察新生儿接种不同剂量乙肝疫苗后不同时间段人群抗体水平变化,采用化学放光法检测血清抗体水平。结果两队列新生儿在全程接种乙肝疫苗后1个月、6个月、12个月,低无应答率接种10μg组均低于接种5μg乙肝疫苗组,乙肝表面抗体滴度接种10μg组均高于接种5μg乙肝疫苗组,免疫后12个月内两组乙肝表面抗体滴度均呈下降趋势,免疫后12个月10μg乙肝疫苗组的乙肝表面抗体阳性率高于接种5μg乙肝疫苗组。结论新生儿接种10μg乙肝疫苗的免疫效果优于5μg乙肝疫苗。
Objective To investigate the immune levels of neonates vaccinated with 10μg and 5μg of Hepatitis B vaccine at different times and to provide a scientific basis for adjusting the immunization schedule of neonates with Hepatitis B vaccine. Methods A case-control study was conducted to observe the changes of antibody levels in different time periods after neonates were vaccinated with different doses of hepatitis B vaccine. The serum antibody levels were detected by chemiluminescence method. Results The newborns of two cohorts were less than the group vaccinated with 5μg hepatitis B vaccine at 1 month, 6 months, 12 months and 10 months after the whole course of hepatitis B vaccine inoculation. The antibody titer against hepatitis B surface was 10μg Inoculation of 5μg hepatitis B vaccine group, the titer of HBsAg in both groups showed a decreasing trend within 12 months after immunization. The positive rate of HBsAg in 10μg hepatitis B vaccine group at 12 months after immunization was higher than that in 5μg hepatitis B vaccine group. Conclusion The immune effect of 10μg hepatitis B vaccine is better than 5μg hepatitis B vaccine.