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本文综合报道硝硫氰胺的不同剂型、不同剂量、不同疗程治疗小白鼠、犬、猴等血吸虫病的实验研究,结果减虫率均达90～100％,治疗后,虫体很快肝移,并形成死虫结节,治毕6个月,未见虫体复苏,疗效高且稳定。而疗效与药物颗粒的大小有直接关系。 通过病理学、组织化学、间接免疫荧光及体外培养等方法观察硝硫氰胺对虫体的作用。发现有直接的杀虫作用,最低致死浓度仅1μg/ml,其杀虫过程首先是使虫体肝移,破坏虫体表膜的组织结构及防御功能,干扰虫体的代谢。呈现糖元减少,琥珀酸脱氢酶,三磷酸腺苷酶活性减弱等改变。实验表明,硝硫氰胺的杀虫机理可能涉及多方面,主要可能是虫体代谢紊乱,以糖代谢为主及表膜的破坏。
In this paper, we report on the experimental study on the treatment of schistosomiasis in mice, canines, monkeys and other different dosage forms of nitrites, different dosages and different courses of treatment. The results showed that the worm reduction rate reached 90-100%. After treatment, , And the formation of dead nodules, 6 months after treatment, no recovery of parasites, high efficacy and stability. The efficacy and the size of drug particles are directly related. Through the pathology, histochemistry, indirect immunofluorescence and in vitro methods to observe the role of nitrite cyanide on parasites. Found to have a direct insecticidal effect, the minimum lethal concentration of only 1μg / ml, the insecticidal process is the first to move the worm body, the destruction of parasites surface membrane structure and defense functions, interfere with the body’s metabolism. Showing glycogen reduction, succinate dehydrogenase, adenosine triphosphate enzyme activity and other changes. Experiments show that the mechanism of nitrosamines insecticide may involve many aspects, the main may be parasites metabolic disorders, mainly to sugar metabolism and the destruction of the membrane.