【摘 要】
：
目的观察氯胺酮预处理对兔脊髓缺血再灌注损伤的保护作用.方法24只日本大白兔随机分为假手术组(A组)、缺血再灌注组(B组)和氯胺酮预处理组(C组),各组均为8只.A组不阻断主动脉
【机 构】
：
武汉大学人民医院,湖北 武汉 430060
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目的观察氯胺酮预处理对兔脊髓缺血再灌注损伤的保护作用.方法24只日本大白兔随机分为假手术组(A组)、缺血再灌注组(B组)和氯胺酮预处理组(C组),各组均为8只.A组不阻断主动脉,B组左肾下阻断主动脉45min,C组左肾下阻断主动脉前10min及开放后即刻静推氯胺酮30mg@kg-1.术后进行后肢神经功能评分和针电极肌电图(EMG)的描记及脊髓形态学改变的观察.结果B组分别同A、C组相比,神经功能和病理学评分均显著性偏低(P<0.01),且同C组相比,后肢EMG亦有显著性病理改变(P<0.01).C组1只动物发生迟发性瘫痪.结论氯胺酮预处理对家兔脊髓缺血再灌注损伤具有一定的保护作用.
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