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瘦素 (leptin)在体内可能参与多种代谢的调节 ,研究发现骨髓中的脂肪细胞亦能合成瘦素 ,揭示瘦素可能参与了骨代谢。另外 ,瘦素可作用于人骨髓间质细胞 ,使其向成骨细胞分化 ,同时抑制该细胞向脂肪细胞分化。体外研究显示瘦素可刺激大鼠骨髓干细胞增殖 ,但最近对瘦素缺乏小鼠 (ob ob)或瘦素受体缺乏小鼠 (db db)的骨密度研究显示瘦素还可能通过中枢对骨形成发挥间接的抑制作用 ,表明瘦素可能从多方面调节骨代谢
Leptin may be involved in the regulation of various metabolic processes in vivo. Studies have found that adipocytes in the bone marrow can also synthesize leptin, revealing that leptin may be involved in bone metabolism. In addition, leptin acts on human bone marrow stromal cells to differentiate into osteoblasts while inhibiting differentiation of the cells into adipocytes. In vitro studies have shown that leptin stimulates the proliferation of rat bone marrow stem cells, but recent studies on the bone mineral density of ob ob or leptin receptor-deficient mice (db db) have shown that leptin may also be administered via the central to the bone The formation of indirect indirect inhibition, indicating that leptin may regulate bone metabolism in many ways