关于口服控释给药研究的内容,主要是考虑开发一种适宜于治疗、具有一定的释药速率和作用时间的给药系统;延长给药系统在吸收部位滞留足够时间;以运送所给药物的全部剂量和清除、以及预防有些药物的肝脏“首过效应”等。近年来人们愈加重视药物在胃中滞留时间,分别提出胃内漂浮胃内膨胀、胃内渗透压控释、瘤胃 With regard to oral controlled release drug delivery research, the main consideration is to consider the development of a suitable treatment, with a drug delivery rate and duration of the drug delivery system; prolonged drug delivery system in the absorption site retention time enough to deliver the given drug The full dose and clearance, as well as the prevention of some drugs in the liver “first pass effect ” and so on. In recent years, people pay more attention to the retention time of drugs in the stomach, floating stomach were proposed intragastric expansion, osmotic pressure controlled release, rumen