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目的通过介绍体内各屏障高度表达的P糖蛋白外排作用对HIV-1蛋白酶抑制剂的影响,探讨如何通过有效调节P糖蛋白,优化对艾滋病患者的治疗。方法查阅国外文献进行总结和归纳。结果综述了P糖蛋白表达对HIV-1蛋白酶抑制剂在体内吸收、分布的影响。结论 P糖蛋白一定程度地阻碍了HIV-1蛋白酶抑制剂在体内的吸收和分布,通过抑制P糖蛋白的活性,可以增加HIV-1蛋白酶抑制剂的化学疗效,未来艾滋病的治疗,P糖蛋白抑制剂的选择和使用将是一项艰巨的任务。
OBJECTIVE: To study the effect of P-glycoprotein efflux on the expression of HIV-1 protease inhibitors in vivo and to explore how to optimize the treatment of AIDS patients by effectively regulating P-glycoprotein. Methods to consult foreign literature to summarize and summarize. Results The effects of P-glycoprotein on the absorption and distribution of HIV-1 protease inhibitors in vivo were reviewed. Conclusions P-glycoprotein inhibits the absorption and distribution of HIV-1 protease inhibitors in vivo to a certain extent. By inhibiting the activity of P-glycoprotein, it can increase the chemotherapeutic effect of HIV-1 protease inhibitors, future treatment of AIDS, P glycoprotein The choice and use of inhibitors will be a daunting task.