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目的探讨自体外周血干细胞移植(APBSCT)治疗多发性骨髓瘤(MM)的临床疗效及安全性。方法1例MM患者接受APBSCT治疗,采用环磷酰胺(CTX)+粒细胞集落刺激因子(G-CSF)方案动员干细胞,CS-3000血细胞分离机采集外周血干细胞并保存于-80℃冰箱;用马法兰200 mg/m2方案预处理后,解冻回输冻存的干细胞。观察患者移植前后的临床疗效。结果动员后获得单个核细胞数(MNC)3.705×108/kg;CD34+细胞数2.56×106/kg。患者获得造血重建,中性粒细胞数(ANC)>0.5×109/L、血小板计数(PLT)>20×109/L的时间分别是12 d、15 d。移植后随访1年患者处于完全缓解(CR)状态。结论APBSCT治疗MM安全有效。
Objective To investigate the clinical efficacy and safety of autologous peripheral blood stem cell transplantation (APBSCT) in the treatment of multiple myeloma (MM). Methods One patient with MM was treated with APBSCT and the stem cells were mobilized by CTX + G-CSF. The peripheral blood stem cells were collected by CS-3000 blood cell separator and stored in -80 ℃ refrigerator. After melphalan 200 mg / m2 was pretreated, the frozen stem cells were thawed and thawed. To observe the clinical effect of patients before and after transplantation. Results After mobilization, the number of mononuclear cells (MNC) was 3.705 × 108 / kg and the number of CD34 + cells was 2.56 × 106 / kg. Hematopoietic reconstitution, neutrophil count (ANC)> 0.5 × 109 / L and platelet count (PLT)> 20 × 109 / L were 12 days and 15 days respectively. One year after transplantation, the patients were in complete remission (CR). Conclusion APBSCT treatment of MM safe and effective.