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目的探讨幽门螺杆菌感染与动脉粥样硬化的关系及危险因素研究,为临床治疗提供参考依据。方法选择2014年1月-2015年12月医院心内科住院的动脉粥样硬化患者200例为动脉粥样硬化组和无动脉粥样硬化患者200例为对照组,动脉粥样硬化组患者根据有无幽门螺杆菌感染分为幽门螺杆菌阳性患者和幽门螺杆菌阴性患者,比较患者临床指标。结果动脉粥样硬化组体重指数、甘油三酯、低密度脂蛋白胆固醇、尿酸、同型半胱氨酸水平均高于对照组(P<0.05),动脉粥样硬化组高密度脂蛋白胆固醇低于对照组(P<0.05);logistic多元回归分析结果显示,高血压、糖尿病、吸烟、幽门螺杆菌感染、低密度脂蛋白胆固醇是动脉粥样硬化的独立危险因素,高密度脂蛋白胆固醇为动脉粥样硬化的独立保护因素(P<0.05);幽门螺杆菌阳性患者总胆固醇、甘油三酯、低密度脂蛋白胆固醇、C-反应蛋白和同型半胱氨酸水平均高于阴性患者(P<0.05)。结论动脉粥样硬化的发生发展与幽门螺杆菌感染关系密切。
Objective To investigate the relationship between Helicobacter pylori infection and atherosclerosis and to study the risk factors for clinical treatment. Methods From January 2014 to December 2015, 200 cases of atherosclerosis hospitalized in Department of Cardiology of our hospital were treated with atherosclerosis and 200 cases without atherosclerosis as the control group. Patients with atherosclerosis were divided according to No Helicobacter pylori infection was divided into Helicobacter pylori-positive patients and Helicobacter pylori-negative patients, the clinical indicators of patients. Results The body mass index, triglyceride, low density lipoprotein cholesterol, uric acid and homocysteine in the atherosclerotic group were higher than those in the control group (P <0.05). The atherosclerosis group had lower HDL cholesterol (P <0.05). Logistic multiple regression analysis showed that hypertension, diabetes, smoking, Helicobacter pylori infection and low density lipoprotein cholesterol were the independent risk factors for atherosclerosis. High-density lipoprotein cholesterol (P <0.05). The levels of total cholesterol, triglyceride, low density lipoprotein cholesterol, C-reactive protein and homocysteine in H.pylori-positive patients were significantly higher than those in negative patients (P <0.05) ). Conclusion The occurrence and development of atherosclerosis are closely related to Helicobacter pylori infection.