目的分析新邵县疑似预防接种异常反应(AEFI)的监测数据,评价监测系统运行情况。方法描述性分析新邵县2012—2014年AEFI的监测资料。结果新邵县2012—2014年共报告AEFI病例128例,报告发生率15.10/10万剂次,共涉及18种疫苗,其中国家免疫规划疫苗9种,共报告85例(66.4%,10.03/10万剂次);非国家免疫规划疫苗9种,共报告43例(33.6%,5.07/10万剂次)。AEFI以一般反应为主(95.3%),共122例;异常反应4例(3.1%),偶合症2例(1.6%),无心因性反应和群体性预防接种异常反应报告。临床表现以发热最多,共77例(60.2%),其次红肿/硬结45例(35.2%),异常反应4例均为过敏性皮疹。监测系统48h报告率82.0%,其他项目均100%;128例中,发生在接种疫苗0~1d占79.7%,2~3d占15.6%,4~15d占4.7%。结论新邵县AEFI监测系统运行正常,疫苗安全性较好,监测质量仍需进一步提高。 Objective To analyze the monitoring data of suspected AEFI in Xinshao County and evaluate the operation of monitoring system. Methods Descriptive analysis of AOSI monitoring data from 2012 to 2014 in Xinshao County. Results A total of 128 cases of AEFI were reported in Xinshao county in 2012-2014, with a reported incidence of 15.10 / 100 000 doses. A total of 18 vaccines were involved, of which 9 were national immunization programs and 85 were reported (66.4%, 10.03 / 10 Million doses); 9 non-state immunization vaccine programs, a total of 43 cases reported (33.6%, 5.07 / 10 000 doses). There were 122 cases in AEFI with general reaction (95.3%), 4 cases with abnormal reaction (3.1%) and 2 cases with coupled disease (1.6%). There was no association between psychogenic reaction and group vaccination. Clinical manifestations to the most fever, a total of 77 cases (60.2%), followed by inflamed / induration in 45 cases (35.2%), abnormal reaction in 4 cases were allergic rash. Monitoring system 48h reported rate of 82.0%, other projects were 100%; 128 cases, occurred in vaccination 0 ~ 1d accounted for 79.7%, 2 ~ 3d accounted for 15.6%, 4 ~ 15d accounted for 4.7%. Conclusion Xinshao County AEFI monitoring system is in normal operation with good vaccine safety and the quality of monitoring needs to be further improved.