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目的 :对香连胶囊原有的生产工艺进行改进 ,以求降低崩解时间。方法 :根据正交试验的结果 ,将香连胶囊原生产工艺中的木香水提法改为水提醇沉法 (含醇量为 6 0 % ) ;将制粒时的稀释剂淀粉改为滑石粉 ;将湿润剂乙醇的浓度由5 0 %改为 95 % ;将助流剂硬脂酸美的加入法改为转动糖衣锅包衣式加入法。结果 :生产工艺改进后 ,明显地缩短了生产周期 ,提高了产品收得率 ,降低了劳动强度和生产成本 ,彻底解决了崩解度不合格的问题。结论 :改进法是可行的。
Objective : To improve the original production process of Xianglian Capsule in order to reduce the disintegration time. Methods: According to the results of the orthogonal test, the wood perfume in the original production process of Xianglian capsule was changed to water extraction and alcohol precipitation (containing 60% alcohol); the starch in the granulation was changed to talc. Powder; the concentration of the wetting agent ethanol was changed from 50 % to 95 %; the adding method of the smoothing agent stearic acid was changed to the rotating sugar coating pan coating adding method. Result: After the improvement of the production process, the production cycle was significantly shortened, the product yield was increased, the labor intensity and production cost were reduced, and the problem of unqualified disintegration degree was completely solved. Conclusion: The improved method is feasible.