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目的研究充血性心力衰竭患者血清肌钙蛋白T(cTnT)和肌钙蛋白Ⅰ(cTnI)水平与心功能的关系及其对预后的判断。方法检测110例不同病因、不同心功能分级的充血性心力衰竭患者的cTnT、cTnI及左室射血分数(LVEF),并与40名健康对照组的结果进行比较。结果心功能Ⅱ级组cTnT为(78.56±25.65)pg/mL,cTnI为(0.85±0.57)ng/mL,LVEF值为57.46%±4.42%;心功能Ⅲ级分别为(249.25±76.21)pg/mL、(3.75±1.83)ng/mL、44.27%±10.13%;心功能Ⅳ级组分别为(375.62±81.29)pg/mL、(8.57±2.56)ng/mL、36.75%±5.66%,与健康对照组[分别为(3.65±0.96)pg/mL、(0.02±0.01)ng/mL、65.52%±8.01%]比较,差异有统计学意义(P<0.01),且心功能越差,cTnT、cTnI浓度越高;cTnT、cTnI与LVEF值均呈负相关,r分别为-0.487、-0.360,差异有统计学意义(P<0.01)。结论检测cTnT、cTnI对于判断充血性心力衰竭患者病情严重程度及预后具有重要的临床价值,是早期评估患者风险的重要方法。
Objective To investigate the relationship between serum cardiac troponin T (cTnT) and troponin Ⅰ (cTnI) levels and cardiac function in patients with congestive heart failure and their prognostic value. Methods The cTnT, cTnI and left ventricular ejection fraction (LVEF) were measured in 110 patients with congestive heart failure of different etiologies and with different cardiac function. The results were compared with those of 40 healthy controls. Results The level of cTnT was (78.56 ± 25.65) pg / mL, the cTnI was (0.85 ± 0.57) ng / mL, the LVEF was 57.46% ± 4.42%, and the level of cardiac function was (249.25 ± 76.21) pg / mL, (3.75 ± 1.83) ng / mL and 44.27% ± 10.13%, respectively. The levels of cardiac function in group Ⅳ were (375.62 ± 81.29) pg / mL and (8.57 ± 2.56) ng / mL and 36.75% ± 5.66% The difference was statistically significant (P <0.01), and the heart function was worse, the cTnT, cTnT and cTnT in the control group [(3.65 ± 0.96) pg / mL, (0.02 ± 0.01) ng / mL, 65.52% ± 8.01% The higher the concentration of cTnI, cTnT, cTnI and LVEF values were negatively correlated, r were -0.487, -0.360, the difference was statistically significant (P <0.01). Conclusion The detection of cTnT and cTnI is of important clinical value in judging the severity and prognosis of patients with congestive heart failure. It is an important method to evaluate the risk of patients early.