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目的:探讨P27KIP1、抑制素-α在Cushing综合征肾上腺皮质病变中的表达及其与肾上腺皮质病变的关系。方法:应用免疫组化方法检测41例Cushing综合征肾上腺皮质病变(腺癌11例,腺瘤21例,增生9例)组织标本中P27KIP1及抑制素-α的表达。结果:P27KIP1及抑制素-α在肾上腺皮质腺癌,腺瘤及增生组织中总阳性情况比较无差异(P>0·05),但表达强度中,P27KIP1及抑制素-α在腺癌表达均显著低于腺瘤及增生(P=0·025及P=0·021);抑制素-α在转移性腺癌中表达显著降低(P=0·004);P27KIP1及抑制素-α存在正相关性(r=0·32,P=0·042)。结论:P27KIP1表达水平低下或缺失可能参与Cushing综合征肾上腺皮质恶性病变的进程,抑制素-α可能可作为判别肾上腺皮质腺癌预后的检测指标,检测P27KIP1、抑制素-α对于鉴别Cushing综合征肾上腺皮质病变良恶性以及预后判别具有重要的参考意义。
Objective: To investigate the expression of P27KIP1 and inhibin-α in adrenocortical lesions of Cushing’s syndrome and its relationship with adrenocortical lesions. Methods: Immunohistochemistry was used to detect the expression of P27KIP1 and inhibin-α in 41 Cushing’s syndrome adrenocortical lesions (adenocarcinoma in 11 cases, adenoma in 21 cases and hyperplasia in 9 cases). Results: The positive rates of P27KIP1 and inhibin-α in adrenocortical adenocarcinoma, adenoma and hyperplasia tissue were no difference (P> 0.05), but the expression of P27KIP1 and inhibin-α in adenocarcinoma Was significantly lower than that of adenoma and hyperplasia (P = 0.025 and P = 0.021). The expression of inhibin-α was significantly decreased in metastatic adenocarcinoma (P = 0.004). There was a positive correlation between P27KIP1 and inhibin-α (R = 0 · 32, P = 0 · 042). CONCLUSIONS: The low or absence of P27KIP1 may be involved in the progression of adrenocortical lesions in Cushing’s syndrome. Inhibin-α may be used as a predictor of the prognosis of adrenocortical adenocarcinoma. The detection of P27KIP1 and inhibin-α may play an important role in the differential diagnosis of Cushing’s syndrome Cortical benign and malignant and prognosis has important reference value.