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目的 探讨喉癌、癌旁组织、声带息肉中抑癌基因 P2 7的表达有无差异 ,揭示 P2 7表达与喉癌临床特征之间的关系。方法 用免疫组织化学 S- P法对 38例喉癌组织、癌旁组织及 2 0例声带息肉组织进行 P2 7检测。结果 1P2 7表达在喉癌和癌旁组织、声带息肉之间有显著性差异 ,癌旁组织和声带息肉之间表达无显著性差异。 2P2 7蛋白低表达与颈淋巴结转移、患者预后有相关性 (P<0 .0 5 ) ,而与病人性别、年龄、吸烟史及病理分化无相关性(P>0 .0 5 )。结论 P2 7是判断喉癌预后的有用指标。
Objective To investigate whether there is any difference in the expression of the tumor suppressor gene P2 7 in laryngeal carcinoma, paracancerous tissues and vocal cord polyps, and to reveal the relationship between the expression of P2 7 and the clinical features of laryngeal carcinoma. Methods Thirty-seven cases of laryngeal carcinoma, adjacent non-cancerous tissues and 20 cases of vocal cord polyp tissues were examined for P2 7 by immunohistochemical S-P method. Results 1P27 expression in the laryngeal cancer and adjacent tissues, vocal cord polyps were significantly different between adjacent tissues and vocal cord polyps expression was no significant difference. There was no correlation between the low expression of 2P27 protein and cervical lymph node metastasis and the prognosis of patients (P <0.05), but no correlation with the gender, age, smoking history and pathological differentiation (P> 0.05). Conclusion P2 7 is a useful indicator to judge the prognosis of laryngeal cancer.