【摘 要】
：
ETS-1 is a transcription factor that is a member of the E26 transformation-specific (ETS) family.Galanin receptor 2 (GalR2),a subtype of receptors of the neuropeptide galanin,has been shown to have an antidepressant-like effect after activation in rodents
【机 构】
：
Department of Neurobiology, Beijing Key Laboratory of Neural Regeneration and Repair, Beijing Labora
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ETS-1 is a transcription factor that is a member of the E26 transformation-specific (ETS) family.Galanin receptor 2 (GalR2),a subtype of receptors of the neuropeptide galanin,has been shown to have an antidepressant-like effect after activation in rodents.Our previous study has shown that overexpression of ETS-1 increases the expression of GalR2 in PC12 phaeochromocytoma cells.However,whether ETS-1 has an antidepressant-like effect is still unclear.In this study,we found that chr onicmild stress (CMS) decreased the expression of both ETS-1 and GalR2 in the ventral hippocampus of rats.Meanwhile,we demonstrated that overexpression of ETS-1 increased the expression of GalR2 in primary hippocampal neurons.Importantly,we showed that overexpression of ETS-1 in the ventral hippocampus counteracted the depression-like behaviors of CMS rats.Furthermore,we found that overexpression of ETS-1 increased the level of downstream phosphorylated extracellular signal-regulated protein kinases 1 and 2 (p-ERK1/2) of GalR2 in the ventral hippocampus of CMS rats.Taken together,our findings suggest that ETS-1 has an antidepressant-like effect in rats,which might be mediated by increasing the level of GalR2 and its downstream p-ERK1/2 in the ventral hippocampus.
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