Deformation characteristics of the Sichuan-Yunnan region during the two periods 1999-2007 and 2007-2009 are analyzed with a block deformation model and GPS velocity profiles.The results show that the direction of the principal compressive strain rate of the Northwest-Sichuan block-the Mid-Yunnan block-the Southwest-Yunnan block was characterized by a clockwise rotation from north to south.The Anninghe and the Zemuhe faults had some shear-strain accumulation.The southern segment of the Xiaojiang fault had mainly strike-slip movement,while the northern segment was mainly accumulating strain.The 2008 Ms8.0 Wenchuan earthquake had some influence on the mid-southern segment of the Lijiang-Xiaojinhe fault,the Anninghe fault and the Jinshajiang fault,but not the Zemuhe fault,the Xiaojiang fault and the Red River fault as much. Deformation characteristics of the Sichuan-Yunnan region during the two periods 1999-2007 and 2007-2009 are analyzed with a block deformation model and GPS velocity profile. The results show that the direction of the principal compressive strain rate of the Northwest-Sichuan block- the Mid-Yunnan block-the Southwest-Yunnan block was characterized by a clockwise rotation from north to south. The Anninghe and the Zemuhe faults had some shear-strain accumulation. The southern segment of the Xiaojiang fault had mainly strike-slip movement, while the northern segment was mainly accumulating strain. The 2008-2008 Wenchuan earthquake had some influence on the mid-southern segment of the Lijiang-Xiaojinhe fault, the Anninghe fault and the Jinshajiang fault, but not the Zemuhe fault, the Xiaojiang fault and the Red River fault as much.