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本文对17例严重烧伤死亡病例的肾脏标本进行了组织学和超微结构观察,结果表明:肾小球显示程度不同但较为一致的病变,表现为系膜区增宽、系膜细胞增生与肥大,毛细血管内皮细胞增大、胞浆增多,腔内有中性粒细胞或单核细胞积聚,由此导致毛细血管袢狭窄或闭塞,引起肾小球缺血。这些改变,本文称之为急性肾小球病变。肾小管显示不同程度的变性、坏死及管型形成。急性肾小球病变与氮质血症的程度有平行关系,提示本组病例肾功能障碍的发生主要系由肾小球病变所致。
In this paper, 17 cases of severe burn death of the kidney specimens were histological and ultrastructural observation, the results showed that: glomerular showed different degrees but more consistent lesions, showing widened mesangial area, mesangial cell proliferation and hypertrophy , Capillary endothelial cells increased, increased cytoplasm, intracavitary neutrophils or monocytes accumulate, resulting in stenosis or occlusion of capillaries, causing glomerular ischemia. These changes, referred to herein as acute glomerular lesions. Tubules showed varying degrees of degeneration, necrosis and tubular formation. Acute glomerular disease and the degree of azotemia have parallel relationship, suggesting that the incidence of renal dysfunction in this group mainly caused by glomerular lesions.