组织、器官来源短缺和移植排斥严重制约了器官移植的临床运用。随着分子免疫学的研究进展,发现有些天然免疫分子与免疫活性细胞接触后能够诱导免疫细胞的凋亡,在形成局部免疫耐受的同时又不会造成全身性免疫抑制,这对克服移植排斥有重要意义。 The shortage of tissue and organ sources and graft rejection severely restrict the clinical application of organ transplantation. With the progress of molecular immunology, we found that some innate immune molecules can induce immune cell apoptosis after contact with immunocompetent cells, which can not cause systemic immunosuppression while forming local immune tolerance, There’s important meaning.