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目的分析鲁北地区妇女宫颈人乳头瘤病毒(HPV)与子宫颈癌流行现状及感染分布情况,为防治及疫苗研制提供依据。方法妇科疾病患者800例,采用导流杂交技术检测HPV-DNA并分型,统计其宫颈HPV感染率(高危型HPV、低危型HPV、单一HPV、多重HPV感染率)、HPV感染者年龄分布。结果 200例感染HPV,感染率为25.00%,其中高危型HPV、低危型HPV感染率分别为20.37%、4.63%;200例感染HPV患者,高危型占81.50%,低危型占18.50%,同时感染占8.50%;20~25、41~45岁为HPV感染多发年龄;单一感染率81.00%,多重感染率19.00%,双重感染13.00%,三重感染5.00%,四重感染1.00%。结论鲁北地区妇女宫颈HPV主要为高危型HPV,且单一HPV感染率较高,多发于20~25、41~45岁。
Objective To analyze the prevalence and infection distribution of cervical papillomavirus (HPV) and cervical cancer in women in Lubei area and to provide basis for prevention and treatment and vaccine development. Methods Eighty-five patients with gynecological diseases were collected. The HPV-DNA was detected by flow-through hybridization and the cervical HPV infection rate (high-risk HPV, low-risk HPV, single HPV, multiple HPV infection) . Results 200 cases were infected with HPV and the infection rate was 25.00%. The infection rates of high-risk HPV and low-risk HPV were 20.37% and 4.63% respectively. 200 cases were infected with HPV, the high-risk type accounted for 81.50%, the low-risk type accounted for 18.50% At the same time infection accounted for 8.50%; 20 ~ 25,41 to 45 years old were multiple age of HPV infection; single infection rate was 81.00%, multiple infection rate of 19.00%, double infection 13.00%, triple infection 5.00%, tetracycline infection 1.00%. Conclusions Cervical HPV in the Lubei area is mainly high-risk HPV, and the single HPV infection rate is high, occurring in 20-25, 41-45 years old.