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羊水细胞培养发现嵌合体时诊断处理应慎重考虑。可能是因为胎儿染色体异常而存在真正嵌合体,也可能是由于母体组织污染,细胞不分离或合子后异常,羊水细胞培养的改变,或未能识别的双卵双胎中异常的一个早期死亡而其滋养细胞残存。羊水中嵌合体并不罕见,除了一级嵌合体(一个异常细胞)之外,二级(一个培养瓶中具有相同改变的多个细胞异常)及三级嵌合体(多个培养瓶中众多细胞异常)发生率分别为0.7%及0.2%。虽然这些异常被看作是真正的嵌合体,但二级嵌合体中80%以上及三级嵌合体40%以上的胎儿及新生儿核型未发现异常。
Amniotic fluid cell culture found chimera diagnosis should be carefully considered. The true chimera may be due to fetal chromosomal abnormalities and may also be due to maternal tissue contamination, cell dissociation or post-synaptic abnormalities, changes in amniotic fluid cell culture, or an abnormally early death in unidentified twins Its trophoblastic cells remain. Chimeras in amniotic fluid are not uncommon except for primary chimeras (an abnormal cell), secondary (multiple cell abnormalities with the same change in one flask), and tertiary chimeras (numerous cells in multiple culture flasks Abnormal) rates were 0.7% and 0.2%. Although these abnormalities are considered as true chimeras, no abnormalities were found in more than 80% of secondary chimeras and more than 40% of third-grade chimeras in fetal and neonatal karyotypes.