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目的:探讨E-cadherin和N-cadherin在非小细胞肺癌(NSCLC)中的表达与临床病理因素的关系。方法:采用SP免疫组化方法检测67例NSCLC及20例肺良性病变组织中E-cadherin和N-cadherin表达。结果:肺良性病变中E-cadherin表达率显著高于肺癌组织(90%vs49.25%P=0.001),N-cadher-in不表达,肺癌N-cadherin表达率为47.76%,两者比较差异有统计学意义,P=0.001。Ⅰ、Ⅱ期病例E-cadherin表达率高于Ⅲ、Ⅳ期病例(43.75%vs20%),差异有统计学意义,P=0.036;N-cadherin表达率显著率低于Ⅲ、Ⅳ期病例(25%vs48.57%),差异有统计学意义,P=0.046。无转移的病例E-cadherin表达率略低于有转移的病例(32.5%vs44.44%),差异无统计学意义,P=0.321;无转移的病例N-cadherin表达率显著低于有转移的病例(32.5%vs62.96%),差异有统计学意义,P=0.014。E-cadherin和N-cadherin在不同组织学类型及不同分化程度肿瘤中的表达率差异无统计学意义。结论:NSCLC中E-cadherin和N-cadherin表达水平与肿瘤的浸润转移密切相关,其中N-cadherin在NSCLC的恶性进程中的作用比E-cadherin更为重要,E-cadherin和N-cadherin尤其N-cadherin是评估NSCLC预后的有用指标。
Objective: To investigate the relationship between the expression of E-cadherin and N-cadherin in non-small cell lung cancer (NSCLC) and clinicopathological factors. Methods: The expression of E-cadherin and N-cadherin in 67 cases of NSCLC and 20 cases of benign lung diseases were detected by SP immunohistochemical method. Results: The positive rate of E-cadherin in lung benign lesions was significantly higher than that in lung cancer tissues (90% vs 49.25%, P = 0.001). The expression of N-cadherin in lung cancer was 47.76% Statistically significant, P = 0.001. The positive rate of E-cadherin expression in stage Ⅰ and Ⅱ was higher than that in stage Ⅲ and Ⅳ (43.75% vs20%), the difference was statistically significant (P = 0.036). The positive rate of N-cadherin expression was lower than that in stage Ⅲ and Ⅳ % vs48.57%), the difference was statistically significant, P = 0.046. The positive rate of E-cadherin in non-metastatic cases was slightly lower than that in metastatic cases (32.5% vs44.44%), the difference was not statistically significant (P = 0.321). The positive rate of N-cadherin in non-metastatic cases was significantly lower than that in metastatic cases Cases (32.5% vs62.96%), the difference was statistically significant, P = 0.014. There was no significant difference in the expression rates of E-cadherin and N-cadherin in different histological types and different degree of differentiation tumors. CONCLUSIONS: The expression of E-cadherin and N-cadherin in NSCLC is closely related to the invasion and metastasis of NSCLC. The role of N-cadherin in malignant progression of NSCLC is more important than that of E-cadherin. The expression of E-cadherin and N-cadherin, especially N -cadherin is a useful indicator for assessing the prognosis of NSCLC.