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卒中是导致病人死亡及致残的重要原因,而卒中预防措施的临床应用证据尚有很大差异。1998年以来有关ACE抑制剂对卒中一级和二级预防随机对照的文献已证明其能有效预防卒中,卒中一级预防这种作用和利尿剂、β阻滞剂和钙阻滞剂相似。ACE抑制剂有效预防卒中的机制可能和其稳定内皮细胞功能、增强内源性纤维蛋白溶解、减少氧化过程及抑制增生和炎症反应等作用有关,这可在稳定动脉粥样硬化斑块中产生有益作用。
Stroke is a major cause of death and disability in patients, and evidence of clinical utility in stroke prevention measures varies widely. References to randomized controlled primary and secondary prevention of ACE inhibitors since 1998 have been shown to be effective in preventing stroke. The primary prevention of stroke is similar to diuretics, beta blockers and calcium blockers. The mechanism by which an ACE inhibitor is effective in preventing stroke may be related to its role in stabilizing endothelial function, enhancing endogenous fibrinolysis, reducing oxidative processes, and inhibiting proliferation and inflammatory responses, which may be beneficial in stabilizing atherosclerotic plaques effect.