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木犀草素(Lut)是白毛夏枯草的有效成分。对多种动物的急慢性炎症模型均有明显抑制作用。对Schultz-Dale反应有抑制作用。对SRS-A和组织胺引起的回肠收缩,分别呈现竞争和非竞争性拮抗。Lut还可提高豚鼠过敏性脑脊髓炎的发病率,促进免疫低下小鼠的抗体形成,和增强静止或由亚适浓度PHA激活的淋巴细胞增殖。Lut的抗炎、抗速发型超敏反应和免疫增强作用,可能是其治疗慢性气管炎具有良效的药理基础,
Luteolin (Lut) is an active ingredient of white hay Prunella. On a variety of animal models of acute and chronic inflammation were significantly inhibited. Inhibit Schultz-Dale response. SRS-A and histamine-induced ileal contraction, respectively, showed competitive and non-competitive antagonism. Lut can also increase the incidence of allergic encephalomyelitis in guinea pigs, promote antibody formation in immunocompromised mice, and increase lymphocyte proliferation at rest or by PHA-activated PHA. Lut’s anti-inflammatory, anti-hair-fasting hypersensitivity and immune enhancement may be its effective pharmacological basis for the treatment of chronic bronchitis,